National Institute of Plant Genome Research
 
    Dr. Gitanjali Yadav
    Staff Scientist III
    Ph.D. National Institute of Immunology (NII)
    Tel: 91-11-26741612,14,17 Ext. - 103
    Direct - 26735103
    Fax: 91-11-26741658
    E-mail: gy@nipgr.ac.in
 Research Interest
Isoprenoid Mediated Stress Responses in Plants
My group is investigating plant stress response mechanisms using a knowledge based computational approach, and our major interest is in the area of terpene diversity and the molecular basis of volatile compound emission. We are trying to understand the various roles played by enzymes in the isoprenoid mediated response pathways by studying their active-site architecture, domain constitution and interactions. In Arabidopsis thaliana, computational systems biology is being used to explore the topology of metabolic, protein-interaction and gene-regulatory networks, in order to identify novel molecular factors responsible for modulating these pathways under stress.
Complex Network Analysis
Network science is now witnessing a tremendous interest in the 'robust, yet fragile' nature of complex systems, arising from the recognition that they are not immune to attacks or failure, and our current interest lies in network resilience or susceptibility, upon perturbation. Insights have been gained through induction of a variety of random and targeted disturbances in hundreds of biological networks, and investigation of their responses under attack. This has enabled us to develop tools for analysis and modeling of perturbations in real world networks and make a foray into the intricate theme of network robustness and mechanisms thereof.
Other Interests
Computational Genomics: In the Next Generation Challenge Programme (NGCP) at NIPGR involving Cicer arietinum genome sequencing, assembly and analysis using next generation technology, the focus of my group is in genome composition, macro- and micro-synteny, gene families, organellar genome insertions and protein evolution.

Computational Ecology: In collaboration with experimental and field biologists, I have initiated work towards modeling of food-webs and myriad plant-animal interactions in nature.

Computational Physiology: Molecular frameworks in diverse floral morphologies have been investigated in Arabidopsis by an integrated systems biological analysis of 'Floral Transition', a major event in the life of a plant from the standpoint of resource allocation and reproductive fitness. We are currently trying to decipher the complete floral network in this plant.
 Career
Staff Scientist - III, NIPGR (April 2010 onwards)
Staff Scientist - II, NIPGR (April 2006-March 2010)
Visiting Scientist - Keck Graduate Institute of Applied Sciences, California (November 2006 to Feb 2007)
Research Associate, NII (July 2005-March 2006)
 Awards & Honors
SERB ' Women Excellence Award' (2013) by Science and Engineering Research Board (SERB), India.
Haryana Yuva Vigyan Ratna Award (2010-11) by the Haryana State Council for Science and Technology, India.
INSA Medal for Young Scientists (2011) [Biochemistry & Biophysics] by the Indian National Science Academy.
Associate of the Indian Academy of Sciences (2010-2014).
Prof. Hira Lal Chakravarty memorial award in Plant Sciences (2010) - by the ISCA (Indian Science Association).
Senior IYBA Award, DBT, India - 2009.
Young Scientist Platinum Jubilee Award (2009) from the National Academy of Sciences India (NASI).
Innovative Young Biotechnologist Award (IYBA), DBT, India - 2005.
Visiting Scientist at The Keck Graduate Institute, Claremont, CA, USA (2006).
Junior and Senior Research Fellowships from CSIR, Govt of India (2000 and 2002).
'Catch Them Young' Fellowship from CSIR (1998-2000)
 Bioinformatics Training
As coordinator of the NIPGR Distributed Information Sub Centre (DISC) facility under DBT's Biotechnology Information System Network (BTISNET) program, I conduct short- and long-term training in the area of Computational Biology, including annual Bioinformatics workshops and hands-on training of students for two to six months. These workshops and studentship programs are designed to help researchers aware of available facilities in plant computational biology and its applications. For more details regarding these workshops, research at the DISC facility or web-resources developed under the BTISNET program, see the BIOINFORMATICS section under FACILITIES menu on the main NIPGR website.
 Group Members
 Former Group Members
 Selected Publications
Thakur JK*, Yadav A and Yadav G* (2013) Molecular recognition by the KIX domain and its role in gene regulation. Nucl. Acids Res. (In Press)
Kumari S, Priya P, Misra G and Yadav G* (2013) Structural and biochemical perspectives in plant isoprenoid biosynthesis. Phytochemistry Reviews. 12: 255-291
Jain M, Misra G, Patel RK, Priya P, Jhanwar S, Khan AW, Shah N, Singh VK, Garg R, Jeena G, Yadav M, Kant C, Sharma P, Yadav G, Bhatia S, Tyagi AK, Chattopadhyay D (2013) A draft genome sequence of the pulse crop chickpea (Cicer arietinum L.). Plant Journal. DOI: 10.1111/tpj.12173
Kumari R, Yadav G, Sharma V & Kumar S (2013) Cytosine hypomethylation at CHG and CHH sites in the pleiotropic mutants of Mendelian inheritance in Catharanthus roseus. Journal of Genetics (Accepted)
Kumar S, Kumari R, Sharma V & Yadav G (2013) Common and Distinguishing Characteristics of Genes and Genomes and Their Evolution in the Genome Sequenced Legumes. Proc Indian Natl Sci Acad. 79 (2): 277-286
Yadav G, Anand S and Mohanty D (2013) Prediction of inter domain interactions in modular polyketide synthases by docking and correlated mutation analysis. Journal of Biomolecular Structure and Dynamics 31(1): 17-29. (Spl Issue: Predictive biology using systems and integrative analysis and methods)
Yadav G* and Babu S (2012) NEXCADE: Perturbation Analysis for Complex Networks. PLoS ONE 7(8): e41827. doi:10.1371/journal.pone.0041827
Kumari S, Shridhar S, Singh D, Farmer R, Hundal J, Priya P, Sharma P, Bhavishi K, Schrick K, and Yadav G*. (2012) The role of lectins and HD-ZIP transcription factors in Isoprenoid based plant stress responses Proc. Ind. Natl. Sci. Acad. 78 (4): 671-691 (Article in Cover Illustration)
Gaur R, Azam S, Jeena G, Khan AW, Chaudhary S, Jain M, Yadav G, Tyagi AK, Chattopadhyay D, Bhatia S (2012) High-throughput SNP discovery and genotyping for constructing a saturated linkage map of chickpea (Cicer arietinum L.). DNA Research (In press).
Chaudhary S, Sharma V, Prasad M, Bhatia S, Tripathi BN, Yadav G, Kumar S (2011) Characterization and genetic linkage mapping of the horticulturally important mutation leafless inflorescence (lli) in periwinkle Catharanthus roseus. Sci. Horti. (in press) Doi: 10.1016/j.scienta.2011.02.025
Garg R, Patel RK, Jhanwar S, Priya P, Bhattacharjee A, Yadav G, Bhatia S et al (2011) Gene discovery and tissue-specific transcriptome analysis in chickpea with massively parallel pyrosequencing and web resource development. Plant Physiol 156: 1661-1678.
Anand S, Prasad MV, Yadav G, Kumar N, Shehara J et al.(2010) SBSPKS: structure based sequence analysis of polyketide synthases. Nucl. Acids. Res. 2010 May 5. [Epub ahead of print]
Shridhar S, Chattopadhyay D and Yadav G* (2009) PLecDom: A program for identification and analysis of plant Lectin Domains. Nucl. Acids. Res. Jul 1;37: W452-8. Epub 2009 May 27.
Kumar S, Mishra RK, Chaudhary S, Pandey R and Yadav G (2009) Co-regulation of Biomass Partitioning by Leafblade Morphology Genes Afila, Multifoliate-pinna, Tendril-less and Unifoliata in Grain Pea Pisum sativum. Proc. Ind. Natl. Sc. Acad, 75 No. 1 pp 15-25.
Yadav G, Gokhale RS and Mohanty D (2009) Towards prediction of metabolic products of Polyketide Synthases: An In Silico analysis. PLoS. Comp. Biol. Apr; Vol 5(4): e1000351.
Yadav G*, Prasad RLA, Jha BK, Rai V, Bhakuni VK and Datta K (2008). Evidence for inhibitory interaction of hyaluronan binding protein 1 (HABP1/p32/gC1qR) with S. pneumoniae hyaluronidase. J. Biol. Chem 284(6): 3897-3905 (*corresponding authors)
Kaur H, Shukla RK, Yadav G, Chattopadhyay D and Majee M (2008) Two divergent genes encoding L-myo-inositol 1 -phosphate synthase1 (CaMIPS1) and 2 (CaMIPS2) are differentially expressed in chickpea. Plant, Cell and Environment 31: 1701-1716.
Chopra T, Banerjee S, Gupta S, Yadav G, Anand S, et al. (2008) Novel Intermolecular Iterative Mechanism for Biosynthesis of Mycoketide Catalyzed by a Bimodular Polyketide Synthase. PLoS Biology 6(7): e163 doi:10.1371/journal.pbio.0060163.
Ansari MZ, Yadav G, Gokhale RS and Mohanty D (2004) NRPS-PKS A knowledge based resource for analysis of non-ribosomal peptide synthetases and polyketide synthases. Nucl. Acids Res. 32: W401-W415.
Yadav G, Gokhale RS and Mohanty D (2003) Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases. J. Mol. Biol. 328: 335-63.
Yadav G, Gokhale RS and Mohanty D (2003) SEARCHPKS: A Program for detection and analysis of polyketide synthase domains. Nucl. Acids Res. 31: 3654-3658.
Saxena P, Yadav G, Mohanty D and Gokhale RS (2003) A new family of type III polyketide synthases in Mycobacterium tuberculosis. J. Biol. Chem. 278: 44780-90.
Yadav G, Gokhale RS and Mohanty D (2004) Protein Science, 13 (1): 185, PS-04; 18th Synposium of the Protein Society, San Diego, California, August 14-18, 2004.
Yadav G, Gokhale RS and Mohanty D (2003) Abstract P9-01, 10th FAOBMB Congress Bangalore (India), Abstracts from International Conference.
Yadav G and Mohanty D (2001) Abstracts of the International Symposium on Crystallography and Bioinformatics in Structural Biology. S9-3